The European Surveillance of Veterinary Antimicrobial Consumption (ESVAC) project collects information on how antimicrobial medicines are used in animals across the European Union (EU). This type of information is essential to identify possible risk factors that could lead to the development and spread of antimicrobial resistance in animals.
The European Medicines Agency (EMA) started this project in April 2010 following a request from the European Commission for the Agency to develop a harmonised approach for the collection and reporting of data on the use of antimicrobial agents in animals from EU and European Economic Area (EEA) Member States.
ESVAC strategy 2016 - 2020 (updated)
EMA has developed an ESVAC strategy for 2016-2020. The strategy takes into account stakeholder feedback provided during public consultation:
- ESVAC vision and strategy 2016-2020
- Overview of comments received on ESVAC vision and strategy 2016-2020
- Draft ESVAC vision and strategy 2016-2020
During the next five years, ESVAC will continue collecting and publishing overall sales data from as many EU and EEA countries as possible.
The strategy aims to enable the analysis of European-level trends in antimicrobial consumption per animal species using data that is standardised between countries. EMA will bring together the best European expertise for harmonising data collection and analysis methodologies and will provide guidance on the collection of data per species, with a specific focus on the three major food-producing ones: pigs, cattle and broilers (poultry).
Latest figures on sales of veterinary antibiotics
EMA publishes an annual report on the sales of veterinary antibiotics. Risk assessors and risk managers in Member States use these reports to inform antimicrobial policy and the responsible use of antimicrobials.
The latest report, published in October 2016, shows that sales of antibiotics for use in animals in Europe fell by 2.4% between 2011 and 2014, despite a considerable increase in a Member State which switched to an improved data collection system in 2014 and registered more sales. In 24 of those countries that provided data for this period, sales fell by 12%:
According to the Member States, the factors that may have contributed to the decline include responsible-use campaigns, increased awareness of the threat of antimicrobial resistance, restrictions of use and targets and changes in animal demographics.
The ESVAC project has grown from reporting data from nine countries for its first report covering 2005-2009 to 28 countries from the European Economic Area and Switzerland for its 2014 report.
As a visual aid to the report, an interactive database allows users to access a summary of the specific ESVAC data they are interested in, including data for a specific country or sales of a particular antimicrobial class. Users can also customise charts, maps and graphs.
- Sales of veterinary antimicrobial agents in 26 EU/EEA countries in 2013
- Sales of veterinary antimicrobial agents in 26 EU/EEA countries in 2012
- Sales of veterinary antimicrobial agents in 25 EU/EEA countries in 2011
- Sales of veterinary antimicrobial agents in 19 EU/EEA countries in 2010
- Trends in the sales of veterinary antimicrobial agents in nine European countries: Reporting period 2005-2009
ESVAC sales data collection form and protocol
In order to obtain standardised and harmonised data on sales of veterinary antimicrobials, the Agency together with the ESVAC national contact points developed a data collection protocol and a data collection template for compilation and submission of data using MS Excel.
ESVAC will launch a call for data in 2016 for the submission of 2015 data.
As of 1 September 2015, the delivery of sales data to ESVAC has been web-based. EMA has revised its ESVAC sales protocol and template for web-based submissions:
- ESVAC web based data collection form (template) (20/06/2016)
- ESVAC web based data collection protocol (20/06/2016)
In principle, the same types of data as before will be collected via the web tool.
Although ESVAC data are now collected via the web tool, the Excel templates for submitting data may be useful for countries which are not a part of ESVAC but are planning to establish a data collection system in their country:
ESVAC population correction unit
The amounts of veterinary antimicrobial agents sold are linked to the animal demographics in each country. In order to normalise the sales data for the animal population that can be subjected to treatment with antimicrobial agents, a population correction unit (PCU) is used in the ESVAC as a proxy for the size of the animal population. The way the PCU is calculated can be seen in Appendix 2 of the first ESVAC report.
Standardised units of measurement
To enable a more detailed analysis of trends in antimicrobial consumption, ESVAC is preparing a system for the collection of harmonised and standardised data on consumption by animal species.
As a first step, EMA has established standardised units of measurement for reporting antimicrobial consumption in specific animal species, called the ‘defined daily dose’ and ‘defined course dose’ for animals. For more information, see Standardised units of measurement for veterinary antimicrobials.
The Agency holds meetings on monitoring the consumption of veterinary antimicrobial agents in Europe, bringing together representatives of Member States and other stakeholders:
- ESVAC stakeholders meeting (02/03/2016)
- ESVAC stakeholders meeting (03/03/2015)
- ESVAC workshop on testing of system for data collection by species (09/02/2015)
- ESVAC stakeholders meeting (05/02/2014)
- ESVAC stakeholders meeting (18/03/2013)
- ESVAC annual network meeting 2012 (14-15/02/2012)
- Report from the Workshop on collection of data on antimicrobial agents by species and on unit(s) of measurement (13-14/10/2011)
- Meeting with stakeholders on monitoring sales of veterinary antimicrobial agents in Europe (28/09/2010)
- Meeting on monitoring of sales of veterinary antimicrobial agents in Europe (25/11/2009)
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- European Centre for Disease Prevention and Control: European Surveillance of Antimicrobial Consumption Network
- European Commission: Antimicrobial resistance
- World Health Organization (WHO) Advisory Group on Integrated Surveillance of Antimicrobial Resistance
- WHO Collaborating Centre for Drug Statistics Methodology: ATCvet
- European Food Safety Authority: Antimicrobial resistance