Use of herbal medicinal products containing toxic, unsaturated pyrrolizidine alkaloids (PAs)

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Public statement

Reference numberEMA/HMPC/893108/2011
Published22/12/2014
KeywordsHerbal medicinal products, pyrrolizidine alkaloids
Description

This document describes chemical, toxicological, pharmacological and pharmacokinetic properties of unsaturated pyrrolizidine alkaloids (PAs). It sets out recommendations for the oral and cutaneous use of herbal medicinal products and traditional herbal medicinal products containing PAs.    


Document history

First version

Current version

Public statement


Overview of comments


Second draft public statement


Overview of comments


Draft public statement

Published: 22/12/2014


Published: 22/12/2014


Published: 14/11/2013


Published: 14/11/2013


Published: 25/10/2012


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