Reduction, elimination or substitution of thiomersal in vaccines

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Current effective version

Adopted guideline

Reference numberCPMP/BWP/2517/00
Effective from31/05/2001
KeywordsThiomersal, vaccines, substitution, elimination, preservative, reduction, comparability, antigenicity, stability, organomercurial

This document concerns the use in vaccines of the antimicrobal preservative thiomersal. It provides general guidance on the reduction, elimination and substitution of this compound, considering quality, efficacy and safety aspects.


A 2016 review of this guideline concluded that it remains up-to-date and relevant.

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