Reduction, elimination or substitution of thiomersal in vaccines

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Current effective version

Adopted guideline

Reference numberCPMP/BWP/2517/00
Published26/04/2001
Effective from31/05/2001
KeywordsThiomersal, vaccines, substitution, elimination, preservative, reduction, comparability, antigenicity, stability, organomercurial
DescriptionThis document concerns the use in vaccines of the antimicrobal preservative thiomersal. It provides general guidance on the reduction, elimination and substitution of this compound, considering quality, efficacy and safety aspects.


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