Assessment of the genotoxic potential of antisense oligodeoxynucleotides

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Reflection paper

Reference numberCHMP/SWP/199726/04
Published20/01/2005
KeywordsGenotoxicity, antisense oligonucleotides, genotoxicity tests, phosphorothioate nucleotides
DescriptionThis document discusses the potential of inducing mutations by antisense oligodeoxynucleotides. It gives recommendtation on the type of mutagenicity testing, if such is deemed necessary.  


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