In vitro investigation of mitochondrial toxicity of anti-HIV nucleoside reverse transcriptase inhibitors

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Current version

Draft reflection paper

Reference numberCHMP/SWP/8212/07
Published13/12/2007
KeywordsMitochondrial toxicity, NRTI, mitochondria, cell culture, in vitro, HIV, HAART, study design
DescriptionThis document reviews recent experiments with in vitro investigations of mitochondrial toxicity of nucleoside/nucleotide reverse transcriptase inhibitors in cell culture models. It provides some principles to consider for the conduct of such studies in order to ensure consistency in testing.


Document history

First version

Current version

Draft reflection paper


Concept paper

Published: 13/12/2007


Published: 24/01/2008

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