Background to the CPMP Position Paper on possible pre-clinical studies to investigate addiction and dependence/withdrawal related to the use of selective serotonin uptake inhibitors (SSRIs)

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Position paper

Reference numberCPMP/2278/00
Published14/12/2000
KeywordsSelective serotonin uptake inhibitor (SSRIs), dependence, neuroadaptation, rewarding properties, addiction
DescriptionThis document defines in detail the character of pre-clinical studies to investigate addiction and dependence/withdrawal related to the use of selective serotonin uptake inhibitors (SSRIs). It gives special consideration to physical dependence, neuroadaptation and rewarding properties of SSRIs.


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