Investigation of drug interactions

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Current effective version

Revision 1 - Adopted guideline


Currently under revision - see below

Reference numberCPMP/EWP/560/95/Rev. 1
Effective from01/01/2013
KeywordsInteraction, metabolism, inhibition, induction, transport, enzyme, transport protein, transporter, absorption, food, distribution, physiologically based pharmacokinetic (PBPK), herbal, summary of product characteristics (SmPC), pharmacodynamic
DescriptionThis document provides advice and recommendations on how to evaluate the potential for drug-food and drug-drug interactions for medicinal products (including herbal medicinal products) and how to translate the results of these evaluations to appropriate treatment recommendations in the labelling.

Document history

Revision 2

Concept paper



Published: 07/04/2017


Deadline for comments: 30/06/2017

Revision 1 

Current version

Adopted guideline


Overview of comments


Draft guideline


Concept paper

In operation: 01/01/2013–present


Published: 02/08/2013


Published: 30/04/2010


Published: 24/07/2008

First versionAdopted guidelineIn operation: 01/06/1998–31/12/2012

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