Antimicrobial resistance in veterinary medicine

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Combatting the threat of antimicrobial resistance, particularly resistance to antibiotics, is a high priority for the European Medicines Agency (EMA) and the European medicines regulatory network. In veterinary medicine, EMA is promoting prudent use of antimicrobials in animals, collecting data on the use of veterinary antimicrobials in the European Union (EU), and providing scientific recommendations on the use of specific antimicrobials in animals.

Antimicrobial resistance is when a microbe evolves to become more or fully resistant to antimicrobials which previously could treat it. Antimicrobials include antibiotics, which kill or inhibit the growth of bacteria. For more information, see Antimicrobial resistance.

Antimicrobial use in animals can contribute to the emergence of resistant bacteria that can be transferred to humans through the food chain or direct contact. This can reduce the effectiveness of antimicrobials for treating human disease.

To limit the development of resistance for the benefit of animal and public health, EMA is promoting the prudent use of antimicrobials in animals and is engaged in numerous activities to address the threat arising from the use of medically important antimicrobials in food-producing animals. 

Strategy on antimicrobials 2016-2020

In October 2016, the Agency published the strategy of the Committee for Medicinal Products for Veterinary Use (CVMP) on antimicrobials for 2016-2020. In this five year period, the CVMP will aim to ensure the availability of effective antimicrobial medicines for the treatment of important infectious diseases of animals, while minimising the risks to animals or humans arising from their use. 

The current and past CVMP antimicrobial strategies can be found below:

In line with this strategy, the Agency has published a revised CVMP guideline for the demonstration of efficacy for veterinary medicines containing antimicrobial substances. This second revision provides further information on the use of antimicrobials in animals that are at risk of being infected (methaphylactic use). The document also clarifies the study requirements for antimicrobials that should be reserved for certain situations only:

Monitoring veterinary antimicrobial consumption

It is important to monitor antimicrobial consumtion to identify possible risk factors that may lead to the development and spread of antimicrobial resistance in food-producing animals. Collecting accurate data on the use of these medicines is an essential first step in developing and monitoring policies on responsible use in the Member States.

Since 2010, the Agency has been leading the European Surveillance of Veterinary Antimicrobial Consumption (ESVAC) project, collecting information on how antimicrobials are used in animals across the EU and the European Economic Area (EEA). 

The European database of sales of veterinary antimicrobial agents provides public access to the ESVAC project data on the sales of veterinary antimicrobials in Member States of the EU and EEA.

Analysis of antimicrobial consumption and resistance

EMA works closely with the European Food Safety Authority (EFSA) and the European Centre for Disease Prevention and Control (ECDC) to analyse the potential relationship between the consumption of antimicrobials by humans and animals and the occurance of antimicrobial resistance. The agencies deliver their findings in joint inter-agency antimicrobial consumption and resistance analysis (JIACRA) reports.

Recommendations on the use of antibiotics in animals

EMA supports the European Commission's action plan against the rising threats from antimicrobial resistance by providing scientific input and recommendations on the use of antibiotics in animals in partnership with other relevant EU bodies. This includes a joint opinion with EFSA on measures to reduce the need to use antimicrobial agents in animal husbandry (also known as the 'RONAFA' opinion). 

Earlier reports published jointly by EMA and European bodies including ECDC, EFSA and the European Commission’s Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) have emphasised the need for the prudent use of antibiotics in animals and the role of basic hygiene, and called for strengthened surveillance of resistance, the development of new antimicrobials and new strategies to combat the spread of resistance:

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