Demonstration of a possible impact of maternally derived antibodies on vaccine efficacy in young animals - Scientific guideline
Table of contents
This document provides guidance on how to demonstrate to which extent MDAs may have an impact on the efficacy of vaccines when administered to animals at an age at which maternally acquired immunity is still present.
Keywords: Maternally acquired immunity, maternally derived antibodies (MDAs), young animals, vaccine interference, vaccine efficacy
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Overview of comments on ‘Reflection paper on the demonstration of a possible impact of maternally derived antibodies on vaccine efficacy in young animals’ (EMEA/CVMP/IWP/439467/2007-CONSULTATION) (PDF/97.31 KB)
First published: 18/03/2010
Last updated: 18/03/2010
EMA/614258/2009 -
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Draft reflection paper on the demonstration of a possible impact of maternally derived antibodies on vaccine efficacy in young animals (PDF/53.77 KB)
Draft: consultation closed
First published: 16/03/2009
Last updated: 16/03/2009
EMEA/CVMP/IWP/439467/2007 -
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Concept paper on the need for requiring data to demonstrate the influence of maternally derived antibodies on the vaccination of very young animals (PDF/77.96 KB)
First published: 23/04/2007
Last updated: 23/04/2007
EMEA/CVMP/IWP/501304/2006-CON.