Public statement on the use of herbal medicinal products containing toxic, unsaturated pyrrolizidine alkaloids (PAs) including recommendations regarding contamination of herbal medicinal products with PAs
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This document provided transitional recommendations for control of pyrrolizidine alkaloids levels due to contamination in herbal medicinal products.
Contamination aspects, partially updated, were later included in the revised version of Public statement EMA/HMPC/893108/2011 (Rev 1 adopted July 2021). For current recommendations, the Public statement on Use of herbal medicinal products containing toxic, unsaturated pyrrolizidine alkaloids (PAs) should be followed, including its recommendations on contamination of herbal medicinal products with pyrrolizidine alkaloids.
Keywords: Herbal medicinal products, pyrrolizidine alkaloids