Assessment of the genotoxic potential of antisense oligodeoxynucleotides - Scientific guideline
HumanScientific advice
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This document discusses the potential of inducing mutations by antisense oligodeoxynucleotides. It gives recommendtation on the type of mutagenicity testing, if such is deemed necessary.
Keywords: Genotoxicity, antisense oligonucleotides, genotoxicity tests, phosphorothioate nucleotides