Background to the CPMP Position Paper on possible pre-clinical studies to investigate addiction and dependence/withdrawal related to the use of selective serotonin uptake inhibitors (SSRIs) - Scientific guideline

This document defines in detail the character of pre-clinical studies to investigate addiction and dependence/withdrawal related to the use of selective serotonin uptake inhibitors (SSRIs). It gives special consideration to physical dependence, neuroadaptation and rewarding properties of SSRIs.

Keywords: Selective serotonin uptake inhibitor (SSRIs), dependence, neuroadaptation, rewarding properties, addiction

Current effective version

Background to the CPMP position paper on possible pre-clinical studies to investigate addiction and dependence/withdrawal related to the use of selective serotonin uptake inhibitors (SSRIs)

Adopted Reference Number: CPMP/2278/00