Investigation of drug interactions

Current effective version

PDF icon<b>Revision 1 - Adopted guideline</b>

Currently under revision - see below

Reference numberCPMP/EWP/560/95/Rev. 1
Published06/07/2012
Effective from01/01/2013
KeywordsInteraction, metabolism, inhibition, induction, transport, enzyme, transport protein, transporter, absorption, food, distribution, physiologically based pharmacokinetic (PBPK), herbal, summary of product characteristics (SmPC), pharmacodynamic
DescriptionThis document provides advice and recommendations on how to evaluate the potential for drug-food and drug-drug interactions for medicinal products (including herbal medicinal products) and how to translate the results of these evaluations to appropriate treatment recommendations in the labelling.


Document history

Revision 2

PDF iconConcept paper

Published: 07/04/2017

Deadline for comments: 30/06/2017

Revision 1

Current version

PDF iconAdopted guideline


PDF iconOverview of comments


PDF iconDraft guideline


PDF iconConcept paper

In operation: 01/01/2013–present


Published: 02/08/2013


Published: 30/04/2010


Published: 24/07/2008

First version PDF iconAdopted guideline In operation: 01/06/1998–31/12/2012


Related content


How useful was this page?

Add your rating