Reduction, elimination or substitution of thiomersal in vaccines - Scientific guideline

Table of contents

This document concerns the use in vaccines of the antimicrobal preservative thiomersal. It provides general guidance on the reduction, elimination and substitution of this compound, considering quality, efficacy and safety aspects.

A 2016 review of this guideline concluded that it remains up-to-date and relevant.

Keywords: Thiomersal, vaccines, substitution, elimination, preservative, reduction, comparability, antigenicity, stability, organomercurial


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