Viral safety of oral poliovirus vaccine (OPV)
|Keywords||Oral poliovirus vaccine (OPV), safety, monkey kidney cell, cell substrates, simian virus 40 (SV4), simian immunodeficiency virus (SIV), adventitious agent, inactivated polivirus vaccine|
This document gives consideration to the safety aspects of oral polio vaccines (OPV). It covers the possibility for introducing PCR testing of OPV for viral contamination.
- European Pharmacopoeia
- ICH Q5A (R1) Quality of biotechnological products: viral safety evaluation of biotechnology products derived from cell lines of human or animal origin
- Testing for simian virus 40 (SV40) in polio virus vaccines