In vitro investigation of mitochondrial toxicity of anti-HIV nucleoside reverse transcriptase inhibitors

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This document reviews recent experiments with in vitro investigations of mitochondrial toxicity of nucleoside/nucleotide reverse transcriptase inhibitors in cell culture models. It provides some principles to consider for the conduct of such studies in order to ensure consistency in testing.

Keywords: Mitochondrial toxicity, NRTI, mitochondria, cell culture, in vitro, HIV, HAART, study design

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