Demonstration of a possible impact of maternally derived antibodies on vaccine efficacy in young animals - Scientific guideline

This document provides guidance on how to demonstrate to which extent MDAs may have an impact on the efficacy of vaccines when administered to animals at an age at which maternally acquired immunity is still present.

Keywords: Maternally acquired immunity, maternally derived antibodies (MDAs), young animals, vaccine interference, vaccine efficacy

Current effective version

Reflection paper on the demonstration of a possible impact of maternally derived antibodies on vaccine efficacy in young animals

Adopted Reference Number: EMA/CVMP/IWP/439467/2007

Document history

Overview of comments on ‘Reflection paper on the demonstration of a possible impact of maternally derived antibodies on vaccine efficacy in young animals’ (EMEA/CVMP/IWP/439467/2007-CONSULTATION)

Reference Number: EMA/614258/2009

Draft reflection paper on the demonstration of a possible impact of maternally derived antibodies on vaccine efficacy in young animals

Draft: consultation closed Reference Number: EMEA/CVMP/IWP/439467/2007

Concept paper on the need for requiring data to demonstrate the influence of maternally derived antibodies on the vaccination of very young animals

Reference Number: EMEA/CVMP/IWP/501304/2006-CON.