How to pay

The European Medicines Agency (EMA) provides guidance to marketing authorisation holders and applicants on how to pay fees levied by EMA.

This content applies to human and veterinary medicines.

For more information, see: 

• Fees payable to the European Medicines Agency

Guidance on how to pay fees to EMA

Guidance on how to pay fees and charges levied by EMA is available for applicants and marketing authorisation holders.

This document is updated in line with the New Fee Regulation, applicable as of 1 January 2025. 

As of this date, EMA requires fees or charges to be paid in their entirety before it can provide the following services:

• Scientific advice
• Certificates of medicinal products
• Parallel distribution

These are also known as services subject to prepayment.

How to pay fees and charges levied by EMA: Guidance to marketing authorisation holders and applicants

Reference Number: EMA/535202/2024

Receiving an invoice from EMA

EMA advises customers to be vigilant about phishing attempts involving emails appearing to be from EMA. If in doubt, please contact EMA's accounts team at [e-mail] to verify the authenticity of any EMA correspondence.

Applicants and marketing authorisation holders being levied a fee by EMA for the first time should contact EMA's accounts team to request a customer account number.

The customer account number is a unique reference number with EMA for financial matters. It is quoted on the invoice and all the related financial correspondence received from EMA. Applicants and marketing-authorisation holders should quote their account number with EMA on each procedural submission cover letter and in all correspondence related to financial matters.

How EMA issues invoices

EMA issues invoices to the customer's billing address held on EMA's file at the date when the fee becomes due.

Invoices for marketing-authorisation fees contain:

• details of the product and type of procedures involved;
• the fee amount and financial information.

Invoices for pharmacovigilance fees contain:

• details of the procedure;
• the total number of chargeable units attributable to the marketing authorisation holder;
• information on any fee exemptions or reductions applicable to the pharmacovigilance fee;
• the fee amount and financial information.

Applicants and marketing authorisation holders requiring a purchase order number or similar references on their invoice are strongly encouraged to add EMA to their purchase order exemption list as a decentralised body of the European Union (EU).

Alternatively, applicants and marketing authorisation holders can issue a standing (blanket) purchase order covering all marketing authorisation and / or pharmacovigilance fees levied by EMA for a given period. They should provide such reference to [e-mail].

The reference can also be provided at the point of e-submitting a procedure to EMA, with the exception of certain procedures. 

Please note that EMA will not accept disputes on the grounds that a purchase order number is not provided. The use of the purchase order system is an internal control process of the applicant. It cannot be used as reason to withhold the payment of EMA’s fees.

Online invoicing portal

EMA has implemented an online invoicing portal to enable customers to:

• get instant access to their account;
• view and print-out invoices;
• view their detailed chargeable units line listing for pharmacovigilance fees;
• raise invoice queries;
• search through archived invoices;
• view payments made.

To register with the EMA invoicing portal, please select 'Register now' on the portal log-in page https://fees.ema.europa.eu/bd/public/zindex.jsp and follow the instructions on screen.

Paying an invoice to EMA

Payments must be made by the payable date indicated on the invoice by bank transfer.

The payment by bank transfer must be made net of all bank charges, withholding taxes and any other deductions, in euro and by means of a transfer to EMA's bank account:

ABN AMRO Bank N.V.
IBAN: NL33 ABNA 0837 2865 06
SWIFT: ABNANL2A

Payments should make clear reference to the invoice number. Alternatively, in the case of single remittance for multiple invoices, a remittance advice must be sent to EMA, by email to [e-mail].

Raising a query on an invoice

Any query arising on the invoice must be notified to EMA as soon as possible via the EMA invoicing portal.

Please refer to EMA's guidance to marketing authorisation holders and applicants on how to pay fees levied by EMA, section 3.

How to pay fees and charges levied by EMA: Guidance to marketing authorisation holders and applicants

Reference Number: EMA/535202/2024