NexGard Combo


esafoxolaner / eprinomectin / praziquantel

This medicine is authorised for use in the European Union.


NexGard Combo is an antiparasitic veterinary medicine used to treat mixed infections with external parasites (fleas, ticks or mites) and internal parasites (tapeworm and roundworms) in cats.

The medicine should only be used in confirmed mixed infections or if cats are at significant risk of mixed infection with external parasites and roundworms and need treatment against tapeworm at the same time. If there is no risk of co-infestation, a narrower spectrum antiparasitic medicine should be considered.

For external parasites, an application of NexGard Combo can treat flea and tick infestation for one month. It can also be used to treat infestations with ear or skin mites and as part of the management of flea allergy dermatitis (an allergic skin reaction to flea bites).

For internal parasites, NexGard Combo can be used to treat infections with tapeworms and roundworms/hookworms in the gut as well as lungworms and a roundworm that infects the bladder. NexGard Combo can also be used to prevent heartworm disease for one month per application.

NexGard Combo contains the active substances esafoxolaner, eprinomectin and praziquantel.

This EPAR was last updated on 16/02/2022

Authorisation details

Product details
NexGard Combo
Agency product number
Active substance
  • eprinomectin
  • esafoxolaner
  • praziquantel
International non-proprietary name (INN) or common name
  • esafoxolaner
  • eprinomectin
  • praziquantel
Anatomical therapeutic chemical veterinary (ATCvet) codes
Publication details
Marketing-authorisation holder
Boehringer Ingelheim Vetmedica GmbH
Date of issue of marketing authorisation valid throughout the European Union
Contact address

55216 Ingelheim am Rhein

Product information

29/11/2021 NexGard Combo - EMEA/V/C/005094 - II/0002/G

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Product information documents contain:

You can find product information documents for centrally authorised human medicines on this website. For centrally authorised veterinary medicines authorised or updated from February 2022, see the Veterinary Medicines Information website.

Pharmacotherapeutic group

  • Eprinomectin, combinations

  • Avermectins
  • Antiparasitic products, insecticides and repellents

Therapeutic indication

For cats with, or at risk from mixed infections by cestodes, nematodes and ectoparasites. The veterinary medicinal product is exclusively indicated when all three groups are targeted at the same time.

Assessment history

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