Switching between superiority and non-inferiority - Scientific guideline

This document addresses the issues of superiority, non-inferiority and equivalence from the perspective of an efficacy trial with a single primary variable.

Keywords: Superiority, non-inferiority, equivalence trials

Current effective version

Points to consider on switching between superiority and non-inferiority

Adopted Reference Number: CPMP/EWP/482/99 Legal effective date: 01/02/2001