Use of macrolides, lincosamides and streptogramins in food-producing animals in the European Union: development of resistance and impact on human and animal health - Scientific guideline

Recommendation on the use of macrolides, lincosamides and streptogramins in food producing and companion animals in the EU. It discusses their effect on the development of resistance to this class of antimicrobial agents in bacterial species that are of importance for human and animal health, and the potential impact on animal and human health.

Keywords: Antibiotics, antimicrobials, macrolides, lincosamides, streptogramins, ketolides, antimicrobial resistance, animals, veterinary medicine

Revision 1

Concept paper on an update to the CVMP’s reflection paper on the use of macrolides, lincosamides and streptogramins (MLS) in food-producing animals in the European Union: development of resistance and impact on human and animal health

Draft: consultation closed Consultation dates: 15/10/2021 to 31/01/2022 Reference Number: EMA/CVMP/AWP/266787/2021

Current version

Reflection paper on the use of macrolides, lincosamides and streptogramins (MLS) in food-producing animals in the European Union development of resistance and impact on human and animal health

Adopted Reference Number: EMA/CVMP/SAGAM/741087/2009 Summary:

Macrolides and lincosamides are used for treatment of diseases that are common in food producing animals including medication of large groups of animals. They are critically important for animal health and therefore it is highly important that they are used prudently to contain resistance against major animal pathogens. In addition, MLS are listed by WHO (AGISAR, 2009) as critically important for the treatment of certain zoonotic infections in humans and risk mitigation measures are needed to reduce the risk for spread of resistance between animals and humans.

Overview of comments received on reflection paper on the use of macrolides, lincosamides and streptogramins (MLS) in food-producing animals in the European Union: development of resistance and impact on human and animal ...

Reference Number: EMA/CVMP/SAGAM/358728/2011

Reflection paper on the use of macrolides, lincosamides and streptogramins (MLS) in food-producing animals in the European Union: development of resistance and impact on human and animal health

Draft Reference Number: EMA/CVMP/SAGAM/741087/2009

Concept paper on the use of macrolides, lincosamides and streptogramins in food-producing animals in the European Union: development of resistance and impact on human and animal health

Reference Number: EMEA/CVMP/SAGAM/113420/2009