Viral safety of oral poliovirus vaccine (OPV) - Scientific guideline

This document gives consideration to the safety aspects of oral polio vaccines (OPV). It covers the possibility for introducing PCR testing of OPV for viral contamination.

EMA has not updated this document as all relevant information is included in the applicable European Pharmacopoeia monographs.

Keywords: Oral poliovirus vaccine (OPV), safety, monkey kidney cell, cell substrates, simian virus 40 (SV4), simian immunodeficiency virus (SIV), adventitious agent, inactivated polivirus vaccine

Current version

Position paper on viral safety of Oral Poliovirus Vaccine (OPV)

AdoptedReference Number: CPMP/BWP/972/98Legal effective date: 01/05/1998