Yervoy is a cancer medicine used to treat the following:
- advanced melanoma (a type of skin cancer) in adults and adolescents from 12 years of age;
- advanced renal cell carcinoma (a kidney cancer) in adults;
- non-small cell lung cancer (NSCLC) in adults that has spread to other parts of the body (metastatic) and has not been treated before.
Yervoy is usually used in combination with nivolumab (another cancer medicine) but it can also be used on its own for melanoma.
For renal cell carcinoma, Yervoy is given to patients who have not been treated before and are at moderate or high risk of their cancer getting worse.
For NSCLC, Yervoy is given in combination with both nivolumab and another cancer medicine. Yervoy contains the active substance ipilimumab.
Yervoy : EPAR - Medicine overview (PDF/152.37 KB)
First published: 25/07/2011
Last updated: 20/11/2020
Yervoy : EPAR - Risk-management-plan summary (PDF/331.58 KB)
First published: 13/11/2019
Last updated: 20/11/2020
|Agency product number||
|International non-proprietary name (INN) or common name||
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Bristol-Myers Squibb Pharma EEIG
|Date of issue of marketing authorisation valid throughout the European Union||
07/01/2021 Yervoy - EMEA/H/C/002213 - PSUSA/00009200/202003
- Annex I - Summary of product characteristics
- Annex IIA - Manufacturing-authorisation holder responsible for batch release
- Annex IIB - Conditions of the marketing authorisation
- Annex IIIA - Labelling
- Annex IIIB - Package leaflet
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Yervoy as monotherapy is indicated for the treatment of advanced (unresectable or metastatic) melanoma in adults, and adolescents 12 years of age and older.
Yervoy in combination with nivolumab is indicated for the treatment of advanced (unresectable or metastatic) melanoma in adults.
Relative to nivolumab monotherapy, an increase in progression-free survival (PFS) and overall survival (OS) for the combination of nivolumab with ipilimumab is established only in patients with low tumour PD-L1 expression.
Renal Cell Carcinoma (RCC)
Yervoy in combination with nivolumab is indicated for the first-line treatment of adult patients with intermediate/poor-risk advanced renal cell carcinoma.
Non-Small Cell Lung Cancer (NSCLC)
Yervoy in combination with nivolumab and 2 cycles of platinum-based chemotherapy is indicated for the first-line treatment of metastatic non-small cell lung cancer in adults whose tumours have no sensitising EGFR mutation or ALK translocation.
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