This medicine is authorised for use in the European Union.


Yervoy is a cancer medicine used to treat the following:

  • advanced melanoma (a type of skin cancer) in adults and adolescents from 12 years of age;
  • advanced renal cell carcinoma (a kidney cancer) in adults;
  • non-small cell lung cancer (NSCLC) in adults that has spread to other parts of the body (metastatic) and has not been treated before.

Yervoy is usually used in combination with nivolumab (another cancer medicine) but it can also be used on its own for melanoma.

For renal cell carcinoma, Yervoy is given to patients who have not been treated before and are at moderate or high risk of their cancer getting worse.

For NSCLC, Yervoy is given in combination with both nivolumab and another cancer medicine. Yervoy contains the active substance ipilimumab.

This EPAR was last updated on 18/01/2021

Authorisation details

Product details
Agency product number
Active substance
International non-proprietary name (INN) or common name
Therapeutic area (MeSH)
Anatomical therapeutic chemical (ATC) code
Publication details
Marketing-authorisation holder
Bristol-Myers Squibb Pharma EEIG
Date of issue of marketing authorisation valid throughout the European Union
Contact address

Plaza 254
Blanchardstown Corporate Park 2
Dublin 15
D15 T867

Product information

07/01/2021 Yervoy - EMEA/H/C/002213 - PSUSA/00009200/202003


Please note that the size of the above document can exceed 50 pages.

You are therefore advised to be selective about which sections or pages you wish to print.

Pharmacotherapeutic group

Antineoplastic agents

Therapeutic indication


Yervoy as monotherapy is indicated for the treatment of advanced (unresectable or metastatic) melanoma in adults, and adolescents 12 years of age and older.

Yervoy in combination with nivolumab is indicated for the treatment of advanced (unresectable or metastatic) melanoma in adults.

Relative to nivolumab monotherapy, an increase in progression-free survival (PFS) and overall survival (OS) for the combination of nivolumab with ipilimumab is established only in patients with low tumour PD-L1 expression.

Renal Cell Carcinoma (RCC)

Yervoy in combination with nivolumab is indicated for the first-line treatment of adult patients with intermediate/poor-risk advanced renal cell carcinoma.

Non-Small Cell Lung Cancer (NSCLC)

Yervoy in combination with nivolumab and 2 cycles of platinum-based chemotherapy is indicated for the first-line treatment of metastatic non-small cell lung cancer in adults whose tumours have no sensitising EGFR mutation or ALK translocation.

Assessment history

Changes since initial authorisation of medicine

Related content

How useful was this page?

Add your rating